Functional Heterogeneity of the Striatum in a Rodent Model of Huntington's Disease: Considerations for Neurological Transplantation

Recent studies utilizing a neurotoxic model of Huntington's disease (HD) in rodents have demonstrated locomotor abnormalities following unilateral lesions of the striatum. The behavioral abnormalities are manifested as an asymmetric rotation ipsilateral to the side of the lesion following apomorphine administration. The current study provides evidence for the dependence of rotational direction on the site of the striatal lesion and suggests factors for consideration in utilizing similar models in future neural transplantation research.